The circular RNA ci RS ‐7 promotes APP and BACE 1 degradation in an NF ‐κB‐dependent manner
نویسندگان
چکیده
منابع مشابه
Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway-a key step in Alzheimer's disease (AD) pathology. However, as both APP/BACE-1 are highly expressed in brain, mechanisms precluding their unabated convergence are unclear. Exploring dynamic localization of APP/BACE-1 in cultured hippocampal neurons, we found that after...
متن کاملCircular RNA and miR-7 in cancer.
MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often deregulated in cancer. The identification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA activity underscores the increasing complexity of ncRNA-mediated regulatory networks. Particularly, the recently identified circular RNA, ciRS-7, which acts as a designated miR-7 inhi...
متن کاملRNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation
BACKGROUND β-Amyloid protein (Aβ) has been shown to potentiate the caspase-3 activation induced by the commonly used inhalation anesthetic isoflurane. However, it is unknown whether reduction in Aβ levels can attenuate the isoflurane-induced caspase-3 activation. We therefore set out to determine the effects of RNA interference-mediated silencing of amyloid precursor protein (APP) and β-site AP...
متن کاملVisualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
Extracellular Aβ deposition is a pathologic hallmark of Alzheimer’s disease and a central tenet of the decades-old amyloid cascade hypothesis positing that neuronal dysfunction, synapse loss, neurofibrillary degeneration and the full manifestation of Alzheimer neuropathology is initiated by Aβ. Aβ is generated by sequential cleavage of APP by the enzymes βand γ-secretase, with BACE-1 cleavage b...
متن کاملIcariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease
OBJECTIVE The purpose of this study was to investigate the effects and pharmacological mechanisms of icariin, which is the main component in the traditional Chinese herb Epimedium, on β-amyloid (Aβ) production in an amyloid precursor protein (APP) transgenic (Tg) mouse model of Alzheimer's disease (AD). METHODS APPV717I Tg mice were randomly divided into a model group and icariin-treated (30 ...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2017
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.14045